ScientiaCME Free CME Courses

Target Audience: All Prescribing Practitioners

Activity Description / Statement of Need:

In this online, self-learning activity:

Cervical dystonia is the most common focal dystonia, characterized by involuntary muscular contractions resulting in abnormal head, neck, and shoulder movements in addition to posture that can cause tremor and pain. Early-onset dystonia can begin in infancy, childhood, or adolescence, and it generally progresses from focal to generalized. Adult-onset dystonia usually affects the upper part of the body; the origin of the dystonia determines the risk of spread. Cervical dystonia may appear as torticollis, laterocollis, anterocollis, or retrocollis. It may be distinguished from nondystonic hand tremor and essential tremor by the absence of limb tremor and the manner of neck movement. However, it is more difficult to distinguish from pseudodystonias, resulting in misdiagnosis and inappropriate treatment.

Target Audience:

The following HCPs: medical neurologists; physician assistants, nurse practitioners, and pharmacists who practice in neurology; and other clinicians who commonly encounter patients with cervical dystonia. 

Activity Description / Statement of Need:
In this online, self-learning activity:

Hospital-acquired pneumonia (HAP) occurs at an estimated rate of five to ten per 1,000 hospital admissions and is the most common cause of hospital-acquired infection in the United States. It is defined as pneumonia that develops at least 48 hours after hospital admission and did not appear to be incubating at the time of admission. A significant subset of HAP that occurs most frequently in intensive care units (ICUs) is ventilator-associated pneumonia (VAP), which is defined as pneumonia that occurs more than 48 to 72 hours after tracheal intubation and is thought to affect approximately 10 to 20% of patients who receive mechanical ventilation for more than 48 hours. Altered mechanical defenses, such as impaired ciliary motion and mucus secretion, increase the susceptibility for acquiring pneumonia in intubated patients, with over 90% of pneumonia episodes that develop in ICUs occurring in patients who are intubated or mechanically ventilated.

Target Audience:
HCPs including: pulmonologists, infectious disease specialists, and intensivists; physician assistants, nurse practitioners, and pharmacists specializing in infectious disease or critical care; and any other healthcare professionals with an interest in or clinically encounter patients with HAP or VAP.

Activity Description / Statement of Need:
In this online, self-learning activity:

Helicobacter pylori (H. pylori) infection is one of the most common infections in the world, affecting approximately 50% of the world’s population and 36% of the U.S. population, with a higher prevalence in Blacks, Hispanics, and those of lower socioeconomic status. Most patients are asymptomatic, but H. pylori is the major cause of gastritis and peptic ulcer disease, and it is a risk factor for duodenal ulcers and gastric cancer. H. pylori may be diagnosed by endoscopy or noninvasive testing, including urea breath testing, stool antigen assay, or H. pylori serology.

Target Audience:
HCPs including: gastroenterologists and primary care providers; physician assistants, nurse practitioners, and pharmacists specializing in gastroenterology; and any other HCPs involved or interested in the treatment of H. pylori infection.

Activity Description / Statement of Need:
In this online, self-learning activity:

Age-related macular degeneration (AMD) is the most common cause of blindness in individuals over the age of 50 years. In the early stages of disease, vision may be gray, hazy, or distorted. As the disease progresses, retinal deterioration can lead to irreversible, bilateral loss of central vision. In the US alone, an estimated 18.3 million people are living with early-stage ARMD, and 1.5 million people are living with late-stage AMD, representing 11.6% and 0.9% of all adults older than 40 years, respectively. In addition to the burden of disability caused by blindness, AMD is also associated with substantial societal and economic costs. In the US, vision loss and blindness incur an economic burden of $134 billion annually, of which $36 billion is attributable to indirect costs such as loss of productivity, injury, and unemployment.

Target Audience:
The following HCPs: comprehensive ophthalmologists and retinal specialists; physician assistants, and nurse practitioners who practice in ophthalmology; and any other HCPs with an interest in or who clinically encounter patients with AMD.

Activity Description / Statement of Need:
In this online, self-learning activity:

Transthyretin-mediated amyloidosis (ATTR) is a progressive, multisystem, life-threatening disorder characterized by the extracellular deposition of misfolded, insoluble amyloid fibrils. The role of the TTR protein is to transport thyroxine and retinol-binding proteins, and it is vital for cognition, nerve regeneration, and axonal growth. TTR itself is innately amyloidogenic even without the presence of genetic mutations, which may account for wild-type ATTR (wtATTR), while a hereditary form of ATTR (hATTR) may be passed to offspring through autosomal dominant inheritance. Left untreated, the average life expectancy of ATTR is 3 to 15 years from symptom onset.

Target Audience:
The following HCPs: neurologists, cardiologists, and hematologists; physician assistants, nurse practitioners, and pharmacists in the aforementioned areas of specialty; and any other HCPs with an interest in or who may clinically encounter patients with ATTR.

Activity Description / Statement of Need:

In this online, self-learning activity:

Thalassemias belong to a group of recessively inherited blood disorders characterized by little or no hemoglobin production and chronic anemia of varying severity. Alpha-thalassemia (AT) is most commonly found in people of Mediterranean, Middle Eastern, Asian, and North African descent. Worldwide, 5% of people are AT carriers, with a much higher prevalence in certain regions (eg, up to 23% in Southeast Asia). AT is typically caused by deletions of one or more α-globin genes, of which there are 4 in total, leading to reduced or abolished α-globin production; nondeletional forms of AT can also occur and are generally more severe. The loss of functional α-globin disrupts the globin chain equilibrium, leading to excess γ- and β-globin chain formation and causing ineffective erythropoiesis.

Target Audience:

The following healthcare professionals: hematologists; physician assistants, nurse practitioners, and pharmacists who practice in hematology; and any other healthcare professionals with an interest in or who may clinically encounter patients with AT.

Activity Description / Statement of Need:
In this online, self-learning activity:

Familial chylomicronemia syndrome (FCS) is an ultrarare genetic disease characterized by the buildup of chylomicrons – the largest lipoprotein – as a result of loss of function of one of five genes responsible for lipolysis. Its estimated prevalence is one in one million people and affects patients of all ages. The clinical presentation of FCS varies but includes patients with triglyceride (TG) levels over 10 times and up to a hundred-fold times the upper limit of normal. Complications include eruptive xanthomas on the trunk and extremities, lipemia retinalis, recurrent abdominal pain, hepatosplenomegaly, fatigue, cognitive disorientation, organ failure, necrosis, and pancreatitis, the latter of which is associated with a five- to 30-percent mortality rate in patients affected by FCS. Unfortunately, due in part to the rarity of the condition, patients are commonly undiagnosed, even by endocrinologists.

Target Audience:
HCPs including: endocrinologists, cardiologists, and primary care physicians; physician assistants, nurse practitioners, and pharmacists who practice in the aforementioned areas of specialty; and those who otherwise have an interest in or commonly care for or clinically encounter patients with FCS.