Neurology MOC Sample Questions

The correct answer is E. Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation. Zinc acetate is the treatment of choice.

Explanation: Treatment is not recommended during pregnancy as risks of treatment by far outweigh the benefit, given that the disease has no impact on fetal health: Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation.

Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation. D-penicillamine is the treatment of choice: Although the initial statement is correct, D-penicillamine is not the treatment of choice, as it has been considered teratogenic (reports of diffuse cutis laxa, severe micrognathia, contractures of all limbs, CNS abnormalities (including agenesis of corpus callosum). Healthy infants nevertheless may be born according to a meta-analysis of 18 Wilson disease patients who had 29 pregnancies and did not have any adverse outcomes.

Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation. Trientene is the treatment of choice: Although the initial statement is correct, Trientene is not the treatment of choice. Trientene is pregnancy category C, and therefore caution should be used.

Although treatment is generally not recommended during pregnancy, D-Penicillamine is harmless to the fetus and could be used safely: This statement is incorrect. Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation. D-penicillamine is not the treatment of choice, as it has been considered teratogenic (reports of diffuse cutis laxa, severe micrognathia, contractures of all limbs, CNS abnormalities (including agenesis of corpus callosum). Healthy infants nevertheless may be born according to a meta-analysis of 18 Wilson disease patients who had 29 pregnancies and did not have any adverse outcomes.

Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation. Zinc acetate is the treatment of choice: This statement is correct. Treatment of Wilson’s disease is recommended during pregnancy, as untreated patients may develop fatal liver failure or hemolytic anemia, while the fetus may develop liver damage and copper accumulation. Zinc acetate is a pregnancy category A drug and thus offers most safety during pregnancy at doses of 50 mg 3 times per day.